{"id":14721,"date":"2023-08-25T11:27:29","date_gmt":"2023-08-25T09:27:29","guid":{"rendered":"https:\/\/www.future-live.com\/inflammation-in-recurrent-cystitis\/"},"modified":"2026-02-06T12:38:04","modified_gmt":"2026-02-06T11:38:04","slug":"inflammation-in-recurrent-cystitis","status":"publish","type":"post","link":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/","title":{"rendered":"Inflammation in recurrent cystitis"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text]<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_65 ez-toc-wrap-center counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Indice<\/p>\n<span class=\"ez-toc-title-toggle\"><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Recurrent_cystitis_the_role_of_inflammation\" title=\"Recurrent cystitis: the role of inflammation\">Recurrent cystitis: the role of inflammation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Proteolytic_enzymes_can_be_useful_in_the_course_of_recurrent_bacterial_cystitis\" title=\"Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis\">Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Clinical_study_on_proteolytic_enzymes\" title=\"Clinical study on proteolytic enzymes\">Clinical study on proteolytic enzymes<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Results\" title=\"Results\">Results<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Conclusions\" title=\"Conclusions\">Conclusions<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#ENZURYL_D-MANNOSIO_sachets\" title=\"ENZURYL D-MANNOSIO sachets\">ENZURYL D-MANNOSIO sachets<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#ENZURYL_CIST_Capsules\" title=\"ENZURYL CIST Capsules\">ENZURYL CIST Capsules<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#Bibliografia\" title=\"Bibliografia\">Bibliografia<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Recurrent_cystitis_the_role_of_inflammation\"><\/span><span style=\"color: #005595;\"><strong>Recurrent cystitis: the role of inflammation<\/strong><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>[\/vc_column_text][vc_column_text]In the course of recurrent cystitis, the inflammatory state at the bladder level, triggered by a bacterial infection, very often tends to persist over time, even when the bacterial component has apparently been eradicated.<\/p>\n<p>This sub-chronic inflammatory state is responsible for a whole series of symptoms consisting of burning, pain, and heaviness in the bladder area that can last for quite long periods and are the cause of significant discomfort in daily life.<\/p>\n<p>In these cases, the use of specific plant substances, rich in proteolytic enzymes capable of promoting a physiological anti-inflammatory and anti-edema action within the urinary system, proves useful.<\/p>\n<p>In particular, Bromelain, extracted from the pineapple stem, Papain, obtained from papaya, and Fungal Protease extracted from the fungus <i data-path-to-node=\"0\" data-index-in-node=\"800\">Aspergillus oryzae<\/i>, are particularly effective as they are each able to act at a specific pH level; that is, they are able to exert their action regardless of the degree of urine acidity in each individual.[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_single_image image=&#8221;9032&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css_animation=&#8221;fadeIn&#8221;][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text]<\/p>\n<div id=\"model-response-message-contentr_110a392e9d95d2fd\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<h2 data-path-to-node=\"0\"><span class=\"ez-toc-section\" id=\"Proteolytic_enzymes_can_be_useful_in_the_course_of_recurrent_bacterial_cystitis\"><\/span>Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<\/div>\n<p>[\/vc_column_text][tm_spacer size=&#8221;xs:30;sm:30;md:30;lg:30&#8243;][vc_column_text]<\/p>\n<div id=\"model-response-message-contentr_07ac5480f92d2fa9\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p data-path-to-node=\"0\">Very often, the therapy for urinary tract infections utilizes antibacterial and antiseptic active ingredients, even though their effectiveness tends to decrease over time. It is therefore necessary to develop alternative treatments to improve the efficacy of the therapy. Systemic treatment with proteolytic enzymes has proven to be effective in treating various urinary tract disorders.<\/p>\n<\/div>\n<p>[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_column_text]<\/p>\n<div id=\"model-response-message-contentr_48d134b47602f99a\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<h3 data-path-to-node=\"0\"><span class=\"ez-toc-section\" id=\"Clinical_study_on_proteolytic_enzymes\"><\/span>Clinical study on proteolytic enzymes<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<\/div>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div id=\"model-response-message-contentr_0b1f2d8dea81d9b3\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p data-path-to-node=\"0\">Sixty women aged between 19 and 45 with recurrent bacterial cystitis were studied and divided into two groups of 30 patients each: the first group received standard antibiotic therapy, while the second group took a preparation based on proteolytic enzymes in addition to the antibiotic.<\/p>\n<p data-path-to-node=\"0\">The evaluation of efficacy was carried out on the 1st, 7th, and 14th day, including monitoring of symptoms, pain intensity, and laboratory tests. During the long-term follow-up (6 months after the conclusion of therapy), the relapse rate was evaluated in both groups.<\/p>\n<\/div>\n<p>[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/p>\n<h4 data-path-to-node=\"0\"><span class=\"ez-toc-section\" id=\"Results\"><\/span>Results<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p data-path-to-node=\"0\">At the beginning of the study, all patients showed clinical and laboratory signs of cystitis. By the 14th day, there was a normalization of parameters in both groups; however, patients who were also taking systemic enzyme therapy showed faster relief of the inflammatory state (reduction in the frequency of urination, urgency, and nocturia) starting from the 7th day of treatment. During the 6-month long-term follow-up, relapses were 30% in the first group and only 13.3% in the second group.<\/p>\n<h4><span class=\"ez-toc-section\" id=\"Conclusions\"><\/span>Conclusions<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p data-path-to-node=\"1\">The study results demonstrated the good efficacy of proteolytic enzyme therapy, which ensures a faster improvement in urinary symptoms and pain, as well as a reduction in recurrences in women with chronic recurrent bacterial cystitis.<\/p>\n<p>[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;12853&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-d-mannosio\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text]<\/p>\n<h2 style=\"text-align: center;\"><span class=\"ez-toc-section\" id=\"ENZURYL_D-MANNOSIO_sachets\"><\/span><span style=\"color: #005595;\">ENZURYL D-MANNOSIO sachets<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&nbsp;<\/p>\n<div id=\"model-response-message-contentr_fe04a3e082f7a51f\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p style=\"text-align: center;\" data-path-to-node=\"0\">Supplement based on D-Mannose and proteolytic enzymes<\/p>\n<\/div>\n<p>[\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-d-mannosio-14-bustine%2F|title:EnzUryl%C2%AE%20D-Mannosio%2014%20sachets|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;11981&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-cist\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text]<\/p>\n<h2 style=\"text-align: center;\"><span class=\"ez-toc-section\" id=\"ENZURYL_CIST_Capsules\"><\/span><span style=\"color: #005595;\">ENZURYL CIST Capsules<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&nbsp;<\/p>\n<div id=\"model-response-message-contentr_441025047516fca4\" class=\"markdown markdown-main-panel enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<p style=\"text-align: center;\" data-path-to-node=\"0\">Supplement based on Hibiscus extract and proteolytic enzymes<\/p>\n<\/div>\n<p>[\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-cist%2F|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(0,85,153,0.8)&#8221;][vc_column][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;]<\/p>\n<h4><span class=\"ez-toc-section\" id=\"Bibliografia\"><\/span><strong><span style=\"color: #ffffff;\">Bibliografia<\/span><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>[\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;]<span style=\"color: #ffffff;\">A.V. Kuzmenko et al- Systemic enzyme theraphy for treatment of women with chronic recurrent bacterial cystitis- Urologiia 2020 apr(2) :35-40<\/span>[\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"[vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Recurrent cystitis: the role of inflammation [\/vc_column_text][vc_column_text]In the course of recurrent cystitis, the inflammatory state at the bladder level, triggered by a bacterial infection, very often tends to persist over time, even when the bacterial component has apparently been eradicated. This sub-chronic inflammatory state is responsible for a whole series of symptoms consisting of burning, pain, and heaviness in the bladder area that can last for quite long periods and are the cause of significant discomfort in daily life. In these cases, the use of specific plant substances, rich in proteolytic enzymes capable of promoting a physiological anti-inflammatory and anti-edema action within the urinary system, proves useful. In particular, Bromelain, extracted from the pineapple stem, Papain, obtained from papaya, and Fungal Protease extracted from the fungus Aspergillus oryzae, are particularly effective as they are each able to act at a specific pH level; that is, they are able to exert their action regardless of the degree of urine acidity in each individual.[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_single_image image=&#8221;9032&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css_animation=&#8221;fadeIn&#8221;][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis [\/vc_column_text][tm_spacer size=&#8221;xs:30;sm:30;md:30;lg:30&#8243;][vc_column_text] Very often, the therapy for urinary tract infections utilizes antibacterial and antiseptic active ingredients, even though their effectiveness tends to decrease over time. It is therefore necessary to develop alternative treatments to improve the efficacy of the therapy. Systemic treatment with proteolytic enzymes has proven to be effective in treating various urinary tract disorders. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_column_text] Clinical study on proteolytic enzymes [\/vc_column_text][vc_column_text] Sixty women aged between 19 and 45 with recurrent bacterial cystitis were studied and divided into two groups of 30 patients each: the first group received standard antibiotic therapy, while the second group took a preparation based on proteolytic enzymes in addition to the antibiotic. The evaluation of efficacy was carried out on the 1st, 7th, and 14th day, including monitoring of symptoms, pain intensity, and laboratory tests. During the long-term follow-up (6 months after the conclusion of therapy), the relapse rate was evaluated in both groups. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text] Results At the beginning of the study, all patients showed clinical and laboratory signs of cystitis. By the 14th day, there was a normalization of parameters in both groups; however, patients who were also taking systemic enzyme therapy showed faster relief of the inflammatory state (reduction in the frequency of urination, urgency, and nocturia) starting from the 7th day of treatment. During the 6-month long-term follow-up, relapses were 30% in the first group and only 13.3% in the second group. Conclusions The study results demonstrated the good efficacy of proteolytic enzyme therapy, which ensures a faster improvement in urinary symptoms and pain, as well as a reduction in recurrences in women with chronic recurrent bacterial cystitis. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;12853&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-d-mannosio\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL D-MANNOSIO sachets &nbsp; Supplement based on D-Mannose and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-d-mannosio-14-bustine%2F|title:EnzUryl%C2%AE%20D-Mannosio%2014%20sachets|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;11981&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-cist\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL CIST Capsules &nbsp; Supplement based on Hibiscus extract and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-cist%2F|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(0,85,153,0.8)&#8221;][vc_column][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;] Bibliografia [\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;]A.V. Kuzmenko et al- Systemic enzyme theraphy for treatment of women with chronic recurrent bacterial cystitis- Urologiia 2020 apr(2) :35-40[\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][\/vc_column][\/vc_row]","protected":false},"author":2,"featured_media":16449,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[156,151],"tags":[155],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Inflammation in recurrent cystitis - Future Live Srl<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inflammation in recurrent cystitis - Future Live Srl\" \/>\n<meta property=\"og:description\" content=\"[vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Recurrent cystitis: the role of inflammation [\/vc_column_text][vc_column_text]In the course of recurrent cystitis, the inflammatory state at the bladder level, triggered by a bacterial infection, very often tends to persist over time, even when the bacterial component has apparently been eradicated. This sub-chronic inflammatory state is responsible for a whole series of symptoms consisting of burning, pain, and heaviness in the bladder area that can last for quite long periods and are the cause of significant discomfort in daily life. In these cases, the use of specific plant substances, rich in proteolytic enzymes capable of promoting a physiological anti-inflammatory and anti-edema action within the urinary system, proves useful. In particular, Bromelain, extracted from the pineapple stem, Papain, obtained from papaya, and Fungal Protease extracted from the fungus Aspergillus oryzae, are particularly effective as they are each able to act at a specific pH level; that is, they are able to exert their action regardless of the degree of urine acidity in each individual.[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_single_image image=&#8221;9032&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css_animation=&#8221;fadeIn&#8221;][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis [\/vc_column_text][tm_spacer size=&#8221;xs:30;sm:30;md:30;lg:30&#8243;][vc_column_text] Very often, the therapy for urinary tract infections utilizes antibacterial and antiseptic active ingredients, even though their effectiveness tends to decrease over time. It is therefore necessary to develop alternative treatments to improve the efficacy of the therapy. Systemic treatment with proteolytic enzymes has proven to be effective in treating various urinary tract disorders. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_column_text] Clinical study on proteolytic enzymes [\/vc_column_text][vc_column_text] Sixty women aged between 19 and 45 with recurrent bacterial cystitis were studied and divided into two groups of 30 patients each: the first group received standard antibiotic therapy, while the second group took a preparation based on proteolytic enzymes in addition to the antibiotic. The evaluation of efficacy was carried out on the 1st, 7th, and 14th day, including monitoring of symptoms, pain intensity, and laboratory tests. During the long-term follow-up (6 months after the conclusion of therapy), the relapse rate was evaluated in both groups. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text] Results At the beginning of the study, all patients showed clinical and laboratory signs of cystitis. By the 14th day, there was a normalization of parameters in both groups; however, patients who were also taking systemic enzyme therapy showed faster relief of the inflammatory state (reduction in the frequency of urination, urgency, and nocturia) starting from the 7th day of treatment. During the 6-month long-term follow-up, relapses were 30% in the first group and only 13.3% in the second group. Conclusions The study results demonstrated the good efficacy of proteolytic enzyme therapy, which ensures a faster improvement in urinary symptoms and pain, as well as a reduction in recurrences in women with chronic recurrent bacterial cystitis. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;12853&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-d-mannosio\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL D-MANNOSIO sachets &nbsp; Supplement based on D-Mannose and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-d-mannosio-14-bustine%2F|title:EnzUryl%C2%AE%20D-Mannosio%2014%20sachets|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;11981&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-cist\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL CIST Capsules &nbsp; Supplement based on Hibiscus extract and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-cist%2F|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(0,85,153,0.8)&#8221;][vc_column][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;] Bibliografia [\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;]A.V. Kuzmenko et al- Systemic enzyme theraphy for treatment of women with chronic recurrent bacterial cystitis- Urologiia 2020 apr(2) :35-40[\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][\/vc_column][\/vc_row]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\" \/>\n<meta property=\"og:site_name\" content=\"Future Live Srl\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FutureLivesrl\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-08-25T09:27:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-06T11:38:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.future-live.com\/wp-content\/uploads\/2023\/08\/donna-viso-sofferente-e-bruciore_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"533\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia ferrari\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia ferrari\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\"},\"author\":{\"name\":\"Sonia ferrari\",\"@id\":\"https:\/\/www.future-live.com\/#\/schema\/person\/36e8a2b85e2477d93307768eaeea6841\"},\"headline\":\"Inflammation in recurrent cystitis\",\"datePublished\":\"2023-08-25T09:27:29+00:00\",\"dateModified\":\"2026-02-06T11:38:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\"},\"wordCount\":832,\"publisher\":{\"@id\":\"https:\/\/www.future-live.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.future-live.com\/wp-content\/uploads\/2018\/05\/donna-che-versa-Bustina-nella-bottiglietta-scaled.jpeg\",\"keywords\":[\"english\"],\"articleSection\":[\"Gynecology\",\"Urology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\",\"url\":\"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/\",\"name\":\"Inflammation in recurrent cystitis - 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Future Live Srl","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/","og_locale":"en_US","og_type":"article","og_title":"Inflammation in recurrent cystitis - Future Live Srl","og_description":"[vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Recurrent cystitis: the role of inflammation [\/vc_column_text][vc_column_text]In the course of recurrent cystitis, the inflammatory state at the bladder level, triggered by a bacterial infection, very often tends to persist over time, even when the bacterial component has apparently been eradicated. This sub-chronic inflammatory state is responsible for a whole series of symptoms consisting of burning, pain, and heaviness in the bladder area that can last for quite long periods and are the cause of significant discomfort in daily life. In these cases, the use of specific plant substances, rich in proteolytic enzymes capable of promoting a physiological anti-inflammatory and anti-edema action within the urinary system, proves useful. In particular, Bromelain, extracted from the pineapple stem, Papain, obtained from papaya, and Fungal Protease extracted from the fungus Aspergillus oryzae, are particularly effective as they are each able to act at a specific pH level; that is, they are able to exert their action regardless of the degree of urine acidity in each individual.[\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_single_image image=&#8221;9032&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; css_animation=&#8221;fadeIn&#8221;][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_column_text] Proteolytic enzymes can be useful in the course of recurrent bacterial cystitis [\/vc_column_text][tm_spacer size=&#8221;xs:30;sm:30;md:30;lg:30&#8243;][vc_column_text] Very often, the therapy for urinary tract infections utilizes antibacterial and antiseptic active ingredients, even though their effectiveness tends to decrease over time. It is therefore necessary to develop alternative treatments to improve the efficacy of the therapy. Systemic treatment with proteolytic enzymes has proven to be effective in treating various urinary tract disorders. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:61;md:60;lg:60&#8243;][vc_column_text] Clinical study on proteolytic enzymes [\/vc_column_text][vc_column_text] Sixty women aged between 19 and 45 with recurrent bacterial cystitis were studied and divided into two groups of 30 patients each: the first group received standard antibiotic therapy, while the second group took a preparation based on proteolytic enzymes in addition to the antibiotic. The evaluation of efficacy was carried out on the 1st, 7th, and 14th day, including monitoring of symptoms, pain intensity, and laboratory tests. During the long-term follow-up (6 months after the conclusion of therapy), the relapse rate was evaluated in both groups. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text] Results At the beginning of the study, all patients showed clinical and laboratory signs of cystitis. By the 14th day, there was a normalization of parameters in both groups; however, patients who were also taking systemic enzyme therapy showed faster relief of the inflammatory state (reduction in the frequency of urination, urgency, and nocturia) starting from the 7th day of treatment. During the 6-month long-term follow-up, relapses were 30% in the first group and only 13.3% in the second group. Conclusions The study results demonstrated the good efficacy of proteolytic enzyme therapy, which ensures a faster improvement in urinary symptoms and pain, as well as a reduction in recurrences in women with chronic recurrent bacterial cystitis. [\/vc_column_text][tm_spacer size=&#8221;xs:60;sm:60;md:60;lg:60&#8243;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;12853&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-d-mannosio\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL D-MANNOSIO sachets &nbsp; Supplement based on D-Mannose and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-d-mannosio-14-bustine%2F|title:EnzUryl%C2%AE%20D-Mannosio%2014%20sachets|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(255,255,255,0.95)&#8221;][vc_column][vc_separator][\/vc_column][vc_column width=&#8221;1\/2&#8243;][vc_single_image image=&#8221;11981&#8243; img_size=&#8221;medium&#8221; onclick=&#8221;custom_link&#8221; css_animation=&#8221;none&#8221; link=&#8221;https:\/\/www.future-live.com\/prodotti\/enzuryl-cist\/&#8221;][\/vc_column][vc_column width=&#8221;1\/2&#8243;][tm_spacer size=&#8221;lg:30&#8243;][vc_column_text] ENZURYL CIST Capsules &nbsp; Supplement based on Hibiscus extract and proteolytic enzymes [\/vc_column_text][tm_spacer size=&#8221;lg:10&#8243;][vc_btn title=&#8221;Learn more&#8221; color=&#8221;primary&#8221; align=&#8221;center&#8221; css_animation=&#8221;none&#8221; link=&#8221;url:https%3A%2F%2Fwww.future-live.com%2Fprodotti%2Fenzuryl-cist%2F|&#8221;][\/vc_column][\/vc_row][vc_row background_color=&#8221;custom&#8221; custom_background_color=&#8221;rgba(0,85,153,0.8)&#8221;][vc_column][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;] Bibliografia [\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][vc_column_text css_animation=&#8221;fadeInDown&#8221;]A.V. Kuzmenko et al- Systemic enzyme theraphy for treatment of women with chronic recurrent bacterial cystitis- Urologiia 2020 apr(2) :35-40[\/vc_column_text][tm_spacer size=&#8221;lg:32&#8243;][\/vc_column][\/vc_row]","og_url":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/","og_site_name":"Future Live Srl","article_publisher":"https:\/\/www.facebook.com\/FutureLivesrl\/","article_published_time":"2023-08-25T09:27:29+00:00","article_modified_time":"2026-02-06T11:38:04+00:00","og_image":[{"width":800,"height":533,"url":"https:\/\/www.future-live.com\/wp-content\/uploads\/2023\/08\/donna-viso-sofferente-e-bruciore_2.jpg","type":"image\/jpeg"}],"author":"Sonia ferrari","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Sonia ferrari","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#article","isPartOf":{"@id":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/"},"author":{"name":"Sonia ferrari","@id":"https:\/\/www.future-live.com\/#\/schema\/person\/36e8a2b85e2477d93307768eaeea6841"},"headline":"Inflammation in recurrent cystitis","datePublished":"2023-08-25T09:27:29+00:00","dateModified":"2026-02-06T11:38:04+00:00","mainEntityOfPage":{"@id":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/"},"wordCount":832,"publisher":{"@id":"https:\/\/www.future-live.com\/#organization"},"image":{"@id":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/#primaryimage"},"thumbnailUrl":"https:\/\/www.future-live.com\/wp-content\/uploads\/2018\/05\/donna-che-versa-Bustina-nella-bottiglietta-scaled.jpeg","keywords":["english"],"articleSection":["Gynecology","Urology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/","url":"https:\/\/www.future-live.com\/en\/inflammation-in-recurrent-cystitis\/","name":"Inflammation in recurrent cystitis - 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