enflog® Patent

enflog® is a mixture of proteolytic enzymes developed to act in synergy and with high specificity toward protein substrates of biological interest. Recently, it has proven capable of counteracting the defense mechanisms implemented by certain bacteria, particularly biofilm formation. Its use serves as an innovative support in contexts where the biofilm represents an obstacle to the effectiveness of conventional therapies for the treatment of bacterial infections.

Thanks to its patented formulation, enflog® can act in a targeted manner on the protein substrates that make up the biofilm matrix, making bacteria more vulnerable and easier to counteract.

The patented enzymatic mixture enflog®

enflog® is a standardized enzymatic mixture with proteolytic activity. It is a complex of carefully selected enzymes:

• Bromelain from pineapple stem
• Papain from papaya
• Fungal protease from Aspergillus oryzae

This precise set of enzymes has been studied to act in synergy and with high specificity.

The patent was granted as its innovation and functional uniqueness were recognized in a new field of application.

In particular, the enflog® enzymatic complex has demonstrated the ability to interact with the biofilm produced by certain bacteria, both by preventing its formation and by promoting its disruption.

Scientific evidence on the efficacy of enflog®

The efficacy of the enflog® enzymatic mixture is supported by scientific studies that have evaluated its action on bacterial biofilm. In particular, one study has demonstrated that enflog® is capable of:

• reduce Escherichia coli biofilm formation by 82.8%
• disrupt a pre-formed biofilm by up to 78.3%

These results highlight how the enzymatic action of enflog® can intervene both in the preventive phase and on already structured biofilms, representing a possible support in control strategies for bacterial infections caused by biofilm-producing microorganisms.