Although conventional therapies provide satisfactory results in the treatment of acute vaginal Candidiasis, there is still interest in preventing relapse. In this study, conducted on a group of women with vaginal Candidosis the strain of Saccharomyces cerevisiae CNCM I-3856 was effective in the control of vaginal candida proliferation and in the prevention of recurrent vaginal Candidosis. This probiotic yeast is well tolerated and easy to use in oral administration

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Saccharomyces cerevisiae CNCM I-3856 as Natural Breakthrough for Vaginal Health: A Clinical Study

AUTHORS: Amélie Cayzeele-Decherf, Fanny Pélerin, and Peter Jüsten – Medical Journal Obstetrics and Gynecology 5(4): 1112, 21 December 2017

Vulvovaginal candidiasis (VVC) is a common and burdensome fungal infection in women. Although conventional therapies exert satisfactory results in curing acute VVC, prevention of relapse remains a concern. The objective of this double-blind, randomized, placebo-controlled pilot study was to evaluate the effect of oral administration of S. cerevisiae CNCM I-3856 in women conventionally treated for VVC. The women received a single conventional antifungal treatment and consumed a placebo or S. cerevisiae CNCM I-3856 once a day for 56 days. Vaginal Candida load was measured at each visit by a vaginal swab, and the proportion of relapses was assessed after 8 weeks (W8). Twenty-two (22) women with confirmed VVC were allocated to a verum (n=13) or a placebo group (n=9). Characteristics were similar at baseline except for vaginal Candida load. Compliance was excellent (98.8 ± 8.0%) and probiotic supplementation was well tolerated. In the verum group, Candida vaginal load significantly decreased from W0 to W4 (p <0.01) and from W0 to W8 (p <0.01) while remaining stable in the placebo group. At W8, 4/13 subjects (31%) relapsed in the verum group vs 6/9 subjects (67%) in the placebo group. S. cerevisiae strain CNCM I-3856 is efficient in the control of vaginal Candida proliferation and in preventing VVC recurrence. This probiotic yeast is well-tolerated and easy to use by oral administration.